Actualizado el 08-02-2010

Líneas de investigación

Molecular basis of the development and progression of NAFLD (non alcoholic fatty liver disease)

... the progression from a benign steatosis to steatohepatitis (NASH), fibrosis, cirrhosis and hepatocarcinoma (HCC)
... deregulatied lipid traffic and metabolism in the liver
... identification of targets with diagnostic and therapeutic value .....functional genomics of NAFLD

Alliances

• University of London, United Kingdom
• Hospital Universitario Santa Cristina, Madrid
• Hospital Reina Sofía, Córdoba
• Instituto Superiore di Sanitá, Roma
• Universidad de Salamanca
• University of Alberta, Canadá
  

Lipidomic analysis and molecular imaging ▲

…. new tools for Lipidomics
…..IMS (Imaging Mass spectrometry) in the liver and brain

Alliances

• Departamento de Física-Química, Facultad de Ciencia y Tecnología, UPV-EHU
• Departamento de Farmacología, Facultad de Medicina, UPV-EHU
• University of Stockholm, Suecia

Functional genomics of SND1and SND p102 ▲

… human SND1 and rat SND p102 are homologue proteins
… multiple roles in transcriptional and postranscriptional regulation, lipoprotein secretion, biogenesis of lipid bodies
… promoter sequence and transcriptional activity
… control of gene expression

Liver regeneration ▲

... family of transcription factors E2F hepatic regeneration
... knochout mice E2F2-/-
... Hedghog signalling in hepatic regeneration
... crosstalk between Hedghog pathway and E2F2 transcription factor

Alliances

• University of Duke, Durham, USA
• Departamento de Genética, Facultad de Ciencia y Tecnología, UPV-EHU

Recent PhD Dissertations  ▲

Yuri Rueda, PhD, 2010. SND p102 proteinak hepatozitoen lipidojariapenaren gain duen araginaren azterketa. Supervisors: Patricia Aspichueta y Olatz Fresnedo. European Doctoral Thesis.

Ainara Cano, PhD, 2009. Role of MAT1A gene in hepatic and organic lipid homeostasis. Supervisors: Patricia Aspichueta y Begoña Ochoa. European Doctoral Thesis

Itsaso García-Arcos, PhD, 2008. Association of SND p102 (Rattus norvegicus) to lipid bodies in hepatic parenchymal cells. Supervisors: Begoña Ochoa y Olatz Fresnedo. European Doctoral Thesis.

Igotz Delgado, PhD, 2007. Role of E2F2 in liver regeneration: DNA microarrays to identify gene expression profiles in E2F2-/- transgenic mice. Supervisors: Olatz Fresnedo y Begoña Ochoa

Xabier Buqué, PhD, 2007. Gene expression profile of hepatic steatosis associated to obesity in Zucker fa/fa rat hepatocytes. Supervisors: Patricia Aspichueta y Begoña Ochoa

Nerea Bartolomé, PhD, 2007. ApoB gene expression in rat hepatocyte during the acute phase response. Supervisors: Yolanda Chico y Begoña Ochoa. Awarded with Premio extraordinario de Doctorado en Ciencias de la Salud

Rosa M. Arin, PhD, 2006. Characterization of A2B receptors for adenosine in rabbit gastric parietal cells. Supervisors: Begoña Ochoa y Ana Isabel Vallejo

Lorena Rodríguez, PhD, 2006. Regulation of the SND p102 gene promoter activity. Supervisors: María José Martínez y Begoña Ochoa. Awarded with Premio extraordinario de doctorado en Ciencias de la salud

Lourdes Palacios, PhD, 2005. Molecular cloning and functional analysis of SND p102 protein in rat hepatocytes. Supervisors: Olatz Fresnedo y Begoña Ochoa